Intratumoral electroporation of plasmid interleukin-12: efficacy and biomarker analyses from a phase 2 study in melanoma (OMS-I100)
نویسندگان
چکیده
منابع مشابه
Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma.
PURPOSE Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer than viral vectors, suffers from low gene transfer efficiency. In vivo electroporation, in preclinical models, significantly enhances gene transfer efficiency while retaining the safety advantages of plasmid DNA...
متن کاملA phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma
PURPOSE Intratumoral interleukin-2 (IL-2) is effective but does not generate systemic immunity. Intravenous ipilimumab produces durable clinical response in a minority of patients, with potentially severe toxicities. Circulating anti-tumor T cells activated by ipilimumab may differ greatly from tumor-infiltrating lymphocytes activated by intratumoral ipilimumab in phenotypes and functionality. ...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2015
ISSN: 1479-5876
DOI: 10.1186/1479-5876-13-s1-o11